Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders
نویسندگان
چکیده
منابع مشابه
The inositol 1,4,5-trisphosphate receptors.
The inositol (1,4,5)-trisphosphate receptors (InsP3R) are the intracellular calcium (Ca2+) release channels that play a key role in Ca2+ signaling in cells. Three InsP3R isoforms-InsP3R type 1 (InsP3R1), InsP3R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals. A single InsP3R isoform is expressed in Drosophila melanogaster (DmInsP3R) and Caenorhabditis elegans (CeInsP3R). ...
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Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are a family of tetrameric intracellular calcium (Ca(2+)) release channels that are located on the sarcoplasmic reticulum (SR) membrane of virtually all mammalian cell types, including smooth muscle cells (SMC). Here, we have reviewed literature investigating IP(3)R expression, cellular localization, tissue distribution, activity regulation, comm...
متن کاملPurified Reconstituted Inositol 1,4,5-Trisphosphate Receptors
Thimerosal, a sulfhydryl oxidizing reagent, has been shown to induce Ca2+ mobilization in several cell types and to increase the sensitivity of intracellular Ca2+ stores to inositol 1,4,54risphosphate (IP,). Using purified IP, receptor (IP,R) protein reconstituted in vesicles, we demonstrate pronounced stimulation by thimerosal of its Ca2+ channel activity. Effects of thimerosal are dependent o...
متن کاملFunctional properties of Drosophila inositol trisphosphate receptors.
The functional properties of the only inositol trisphosphate (IP(3)) receptor subtype expressed in Drosophila were examined in permeabilized S2 cells. The IP(3) receptors of S2 cells bound (1,4,5)IP(3) with high affinity (K(d)=8.5+/-1.1 nM), mediated positively co-operative Ca(2+) release from a thapsigargin-sensitive Ca(2+) store (EC(50)=75+/-4 nM, Hill coefficient=2.1+/-0.2), and they were re...
متن کاملActivating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate.
C calcium (Ca2 ) is a focal point of many signal transduction pathways and modulates a diverse array of cellular activities ranging from fertilization to cell death (1). Cells generate Ca2 signals through both internal and external Ca2 sources. In most cell types, the major internal Ca2 stores are the endoplasmic reticulum sarcoplasmic reticulum (ER SR). One mechanism for mobilizing such stores...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2018
ISSN: 1742-464X
DOI: 10.1111/febs.14366